Pathology Notes

Practice questions Ia answers, female genital tract Pathology of vulva, vagina and cervix © Jun Wang, MD, PhD 1. D. Multinucleation, chromatin margining with ground glass appearing nuclei, as well as molding of nuclei are characteristic for herpes infection . Candida infection usually has fungal hyphae. Decidualization of cervix is characterized by decidual cells with abundant pale granular cytoplasm, but no abnormal nuclear morphology. Human papillomavirus infection will cause cervical intraepithelial neoplasia , endocervical adenocarcinoma in situ , and most of cervical carcinomas . Depending on grade, these lesion usually have enlarged hyperchromic nuclei with irregular nuclear membrane, with various amount of cytoplasm. 2. C. Maternal genital tract herpes infection is a risk factor for neonatal herpes. 3. D. Pruritic pink skin nodules with eosinophilic homogenous cytoplasmic inclusion is consistent with molluscum contagiosum . It is caused by molluscum contagios

Practice questions Ia, female genital tract Pathology of vulva, vagina and cervix © Jun Wang, MD, PhD 1. Use this case for the next two questions. A 22-year-old woman presents with watery vaginal discharge for 2 weeks. She is in her third trimester of pregnancy. She has a history of type I diabetes since age 14, and gonorrheal urethritis 2 years ago. She is sexually active and has been living with her most recent partner for a month. Physical examination reveals no lesion in the anogenial area. Colposcopic examination reveals a 0.8 cm ulcer at the cervix with contact bleeding. Biopsy of the ulcer reveals diffuse neutrophilic infiltrate with scattered atypical squamoid multinucleated cells with ground glass appearing nuclear inclusion. The peripheral of these nuclei are much darker than the central portion. The nuclear membrane is smooth although slightly irregular. What is most likely causing these changes? A. Candida infection B. Decidualization C. Gonorrhea infection