Lymphoid neoplasms

Lymphocytic neoplasms

Updated: 05/17/2020

© Jun Wang, MD, PhD


Terminology
  • Lymphoma: Proliferations forming discrete tissue masses
  • Leukemia: Widespread involvement of the bone marrow and usually the peripheral blood
  • Any "lymphoma" can present with or evolve to a leukemic picture, and any "leukemia" can occasionally present with a mass lesion
  • Other hematology terms
Important risk factors
  • Immunodeficiency (primary or secondary)
  • Autoimmune disorders
  • Viruses (HIV, KSHV/HHV8, HTLV-1)
  • H. pylori infection
  • Radiation
  • Chemotherapy
Diagnostic approaches
  • Complete history, especially those with possible epidemic characters, such as Burkitt lymphoma
  • CBC, Bone marrow
  • Morphology/immunohistochemistry
  • Immunofluorescence flow cytometry
  • Cytogenetic studies
  • Molecular studies
Commonly used markers
  • All lymphomas: CD45
  • B-cell neoplasms: CD5, CD10, CD19, CD20, CD79a, CD23, bcl2, bcl6, cyclin D1, light chains
  • T-cells: CD2, CD3, CD4, CD8, CD5
  • Hodgkin lymphoma: CD15, CD30
  • Plasma cell neoplasms: CD38, CD138, light chains
Key diagnostic considerations
  • Cell count
  • Morphology/immunohistochemistry
  • Flow cytometry profiles
  • Molecular abnormality
Some lymphocytic neoplasms
B-cell acute lymphoblastic leukemia/lymphoma
T-cell acute lymphoblastic leukemia/lymphoma
  • Mature B-cell neoplasms, including plasma cell neoplasms
Chronic lymphocytic leukemia/Small lymphocytic lymphoma
Follicular lymphoma
Mantle cell lymphoma
Marginal zone lymphoma
Hairy cell leukemia
Diffuse large B cell lymphoma 
Primary effusion lymphoma
Burkitt lymphoma
Multiple myeloma
Plasmacytoma
Monoclonal gammopathy of undetermined significance (MGUS)
Lymphoplasmacytic lymphoma
  • Mature T-cell and NK-cell neoplasms
Anaplastic large-cell lymphoma (ALK Positive)
Peripheral T-cell lymphoma, not otherwise specified
Adult T-cell leukemia/lymphoma
Large granular lymphocytic leukemia
Extranodal NK/T cell lymphoma, nasal type
Mycosis fungoides
  • Posttransplantation lymphoproliferative disorders (PTLDs)
Practice questions I
Practice questions II
Back to contents


Comments

Post a Comment

Popular posts from this blog

Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4. Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas Multiple endocrine neoplasms 14. B
Read more

Female genital tract

Pathology of female genital tract   Updated: 01/23/2024 © Jun Wang, MD, PhD Key anatomic features Opened channel, pathological basis for pelvic inflammatory disease Cervix: exocervix, endocervix, transformation zone Uterus: fundus, body Fallopian tube: intramural, isthmus, ampulla, infundibulum, fimbriae Placenta: umbilical cord, fetal membrane, placenta Key histologic features Stratified squamous epithelium from vulva to exocervix Simple columnar epithelium from endocervix to fimbriae Uterine corpus Endometrium: Glands, stroma Myometrium Perimetrium: Mesothelium/peritoneum Ovaries: three components Epithelium (mesothelium) Stroma Germ cells (follicles) Placenta: Cytotrophoblast, syncytiotrophoblast, intermediate trophoblast Infectious/inflammatory diseases Diseases of vagina and vulva Molluscum contagiosum Lichen sclerosus Paget disease Sarcoma botryoides Squamous cell carcinoma Diseases of cervix Cervical intraepithelial neopla
Read more

Neoplasms of respiratory tract

Neoplasms of respiratory tract   Updated: 11/14/2022 © Jun Wang, MD, PhD Anatomy Nasal cavity Nasopharynx Oropharynx Laryngopharynx Larynx Trachea and bronchi Lungs Histology Squamous mucosa Respiratory mucosa May have abundant lymphoid tissue in pharynx Type I and Type II pneumocytes Key risk factors Human papillomavirus: Squamous cell carcinoma, squamous cell papilloma Epstein Barr virus: Nasopharyngeal carcinoma Smoking Tumors of nasal cavity and nasopharynx Olfactory neuroblastoma Nasopharyngeal angiofibroma Sinonasal papilloma NUT midline carcinoma Nasopharyngeal carcinoma Tumors or tumor like lesions of larynx Vocal cord polyp Squamous papilloma Squamous cell carcinoma Branchial pouch/cleft anomalies Branchial cyst Thyroglossal duct cyst Neoplasms of lung Squamous cell carcinoma Adenocarcinoma Large cell carcinoma Small cell carcinoma Carcinoid Lymphangioleiomyomatosis Neoplasms of pleura Mesothelioma
Read more