Pathology Notes

Practice question answers Pathology of breast III © Jun Wang, MD, PhD   1. B. This lesion is characterized by stretched/compressed ducts in a background of markedly proliferated hypocellular fibrous tissue. These features are consistent with fibroadenoma . Diabetic mastopathy is commonly seen in patient with type I diabetes and is characterized by dense lymphocytic infiltration surrounding normal appearing ducts. Fibrocystic changes is a group of pathological processes including stromal fibrosis and cyst formation. Usual ductal hyperplasia has increased layers of benign ductal epithelial cells. Invasive ductal carcinoma has ducts with irregular shape and irregular arrangement, suggestive of stromal invasion. Invasive lobular carcinoma has atypical epithelial cells forming single files in stroma.   2. D. Benign ducts/lobules and non-invasive proliferations have intact myoepithelial layer located between luminal cells and basement membrane. Markers for myoepithe...

Practice question Pathology of breast III © Jun Wang, MD, PhD   1. Use this image for the next two questions . A 42-year-old woman presents to the clinic with a left breast mass for 1 month. She does not have history of trauma. She has had type 2 diabetes for 5 years and has been treated with metformin. Her family history is significant for multiple cancers including endometrial carcinoma and benign ovarian tumors. Physical examination reveals a 2.5 cm mobile firm mass at the outer upper   quadrant of her left breast. No other abnormalities are noted. An image of her biopsy is shown. What is the diagnosis?  (No machine-readable author provided. KGH assumed (based on copyright claims)., CC BY-SA 3.0 <http://creativecommons.org/licenses/by-sa/3.0/>, via Wikimedia Commons) A. Diabetic mastopathy B. Fibroadenoma C. Fibrocystic changes D. Invasive ductal carcinoma E. Invasive lobular carcinoma F. Usual ductal hyperplasia 2. A 42-year-old woman pre...

Practice question Pathology of breast II © Jun Wang, MD, PhD 1. Use this case for the next two questions . A 42-year-old woman presents with a pruritic rash on her left nipple for 2 weeks. She has a history of type 2 diabetes and multiple skin melanomas. Physical examination reveals a 0.3 ulcerated area of the left nipple in a background of eczematous changes. No palpable breast mass or axillary lymphadenopathy is identified. Biopsy of the nipple reveals scattered large atypical cells with pale cytoplasm and enlarged irregular hyperchromic nuclei in the epidermis. Scattered neutrophils and lymphocytes are seen at the dermal epidermal junction. Per immunohistochemistry studies, these large pale cells are positive for cytokeratin, but negative for S-100. Special stain reveals no evidence of fungal hyphae. What is the diagnosis? A. Contact dermatitis B. Dermatophytosis C. Melanoma in situ D. Mycosis fungoides E. Paget’s disease 2. A 42-year-old woman presents w...