Practice question Pathology of breast II
Practice question Pathology of breast II © Jun Wang, MD, PhD 1. Use this case for the next two questions . A 42-year-old woman presents with a pruritic rash on her left nipple for 2 weeks. She has a history of type 2 diabetes and multiple skin melanomas. Physical examination reveals a 0.3 ulcerated area of the left nipple in a background of eczematous changes. No palpable breast mass or axillary lymphadenopathy is identified. Biopsy of the nipple reveals scattered large atypical cells with pale cytoplasm and enlarged irregular hyperchromic nuclei in the epidermis. Scattered neutrophils and lymphocytes are seen at the dermal epidermal junction. Per immunohistochemistry studies, these large pale cells are positive for cytokeratin, but negative for S-100. Special stain reveals no evidence of fungal hyphae. What is the diagnosis? A. Contact dermatitis B. Dermatophytosis C. Melanoma in situ D. Mycosis fungoides E. Paget’s disease 2. A 42-year-old woman presents w...