Pathology of breast

Pathology of breast
Updated:01/12/2019
© Jun Wang, MD, PhD

Anatomy/histology
  • Specialized sweat glands
  • Suspensory ligaments: linking skin to fascia of pectoralis major and pectoralis minor
  • Lymphatic drainage
Axillary lymph nodes: majority of drainage
Internal thoracic lymph nodes
Posterior intercostal
Supraclavicular nodes
  • Terminal duct lobular unit
  • Glandular cells: secretion
  • Myoepithelial cells: assist in mild ejection, absent in invasive carcinoma
Clinical presentations
  • Pain: physiological or pathological, usually due to inflammation if pathological
  • Mass: benign or malignant
  • Nipple discharge
Galactorrhea: Drugs, hyperprolactinemia (pituitary tumor), etc
Bloody discharge: Probably intraductal papilloma
Other discharge: Ductal ectasia, fibrocystic changes, neoplasms
Non-neoplastic breast lesions
Acute mastitis/abscess
Lymphocytic mastopathy
Fat necrosis
Idiopathic granulomatous mastitis
Proliferative epithelial lesions
Paget disease of breast
Carcinoma in situ
Invasive carcinoma
Neoplastic epithelial/mesenchymal lesions


Practice question I
Practice question II

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