Practice questions answers Male reproductive system II
Practice questions answers Male reproductive system II © Jun Wang, MD, PhD 1. C. Large atypical cells with clear cytoplasm limited within the tubules without spermatogenesis is most consistent intratubular germ cell neoplasia . Embryonal carcinoma is characterized by primitive epithelial cells with minimal differentiation and positive reactivity to CD30 and cytokeratin. Hairy cell leukemia has “fried egg” appearance, but usually are seen in marrow, in a background for pancytopenia. Seminoma cells have same morphology as intratubular germ cell neoplasia , but the tumor is not limited to tubules. Teratoma has differentiated tissue, such as skin and adnexa, etc. None of these will be limited to tubules. 2. D. Sheets of large testicular tumors with round nuclei and clear cytoplasm is highly suggestive of seminoma , unless a secondary neoplastic components are identified. These tumor cells are positive for PLAP, KIT and OCT3/4. Diffuse large B cell lymphoma is th...