Burkitt Lymphoma

Burkitt Lymphoma
Updated: 8/18/2024
© Jun Wang, MD, PhD

General features
  • Highly aggressive
  • Either endemic, sporadic or immunodeficiency-associated
Endemic: Tropical regions, esp parts of Africa and Asia, 95% are EBV positive
Sporadic: US and Western Europe, young adults and children; high association with EBV in Brazil
Immunodeficiency associated: Adults, often HIV+
Clinical presentations
  • Endemic: Jaw or facial bone tumor, bone marrow involvement in recurrent or treatment resistant disease. 
  • Sporadic: Abdominal mass and ascites. Also diffuse lymphadenopathy; bone marrow and CNS involvement common in recurrent or treatment resistant disease
  • Immunodeficiency-related: Signs or symptoms related to the underlying immunodeficiency, more often involve lymph nodes, bone marrow, and CNS
Key pathogenesis
  • EBV
  • HIV if immunodeficiency-associated
Key morphological features
Markers
  • Positive: CD10, CD19, CD20, almost 100% Ki-67 (proliferation marker), EBER
  • Negative: Cytokeratins
Genetic abnormalities
  • Translocation involving 8q24, C-myc
  • Usually involve one of the heavy or light chain immunoglobulin gene loci
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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas...
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Anemia

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Lymphoid neoplasms

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