Chronic immune thrombocytopenia

Chronic immune thrombocytopenia 

Updated: 07/24/2023

© Jun Wang, MD, PhD

General features
  • Typically in adults aged 20-40 years
  • More common in women
  • Usually do not have history of viral infection
  • Associated with alterations in immune homeostasis
  • Diagnosis of exclusion in patients with isolated thrombocytopenia
Clinical presentations
  • Insidious onset, usually NO precipitating causes
  • Most commonly bleeding in skin or mucosa
  • Severe hemorrhage uncommon
  • May have splenomegaly
Key pathogenesis
  • Clonal expansion of CD8+ cytotoxic T cells may act independently of autoantibodies
  • Autoantibodies against platelet GPIIb/IIIa or GPIb/IX
  • Reduced platelet lifespan due to antibody-mediated destruction
  •  Impaired platelet production due to megakaryocytes damage
Key Laboratory findings
  • Isolated thrombocytopenia
  • Positive anti-platelet antibodies
  • Negative anti-platelet tests could NOT rule out ITP
Key morphological features



Back to thrombocytopenia
Back to bleeding disorders
Back to contents

Comments

Popular posts from this blog

Contents

Anemia

Lymphoid neoplasms