Diffuse Large B Cell Lymphoma

Diffuse Large B Cell Lymphoma 

Updated: 08/24/2020

© Jun Wang, MD, PhD

General features
  • Most common non-Hodgkin lymphoma
  • High grade
  • Fast growing, aggressive
  • Either de novo or transformed from other low grade lymphoma
  • Most common testicle tumor in patient older than 65
  • WHO has subclassifications
Clinical presentations
  • Rapid growing mass, nodal or extranodal
  • Systemic "B" symptoms: Fever, weight loss, drenching night sweats
Key pathogenesis
  • Bcl 6 associated NF-kB pathway
Key morphological features of tumor cells
Markers
  • Positive: B cell markers CD19, CD20
  • Negative: T cell markers CD3, CD4, CD8
  • Negative: Epithelial markers: cytokeratin, etc
  • High proliferative index per ki67, but less than 100%
Genetic abnormalities
  • Various
  • Translocations involving bcl2 or bcl 6


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Contents

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Anemia

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Practice questions Anemia I

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