Follicular Lymphoma

Follicular Lymphoma 

Updated: 05/21/2025

© Jun Wang, MD, PhD

General features
  • Most common of non-Hodgkin lymphoma in US
  • Originates from germinal/follicular center B cells
  • May transform to diffuse large B cell lymphoma
Clinical presentations
  • Nonspecific, including lymphadenopathy, mass, etc
  • Bone marrow involvement common
Key morphological features of tumor cells
Markers
  • Positive: CD10, CD19, CD20, light chain restriction
  • Negative: CD5, CD23, cyclin D1
  • Bcl2 within follicles (Normally negative)
Genetic abnormalities
  • Bcl2
  • KMT2D
  • MLL2
  • t(14;18)(q32;q21): IgH/bcl2, Overexpressing bcl2
Negative prognosis indicator
  • Marrow involvement
  • Anemia
  • High b-microglobulin


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Lymphoid neoplasms

Myeloid neoplasms