Follicular Lymphoma

Follicular Lymphoma 

Updated: 05/21/2025

© Jun Wang, MD, PhD

General features
  • Most common of non-Hodgkin lymphoma in US
  • Originates from germinal/follicular center B cells
  • May transform to diffuse large B cell lymphoma
Clinical presentations
  • Nonspecific, including lymphadenopathy, mass, etc
  • Bone marrow involvement common
Key morphological features of tumor cells
Markers
  • Positive: CD10, CD19, CD20, light chain restriction
  • Negative: CD5, CD23, cyclin D1
  • Bcl2 within follicles (Normally negative)
Genetic abnormalities
  • Bcl2
  • KMT2D
  • MLL2
  • t(14;18)(q32;q21): IgH/bcl2, Overexpressing bcl2
Negative prognosis indicator
  • Marrow involvement
  • Anemia
  • High b-microglobulin


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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas...
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Lymphoid neoplasms

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Myeloid neoplasms

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