Follicular Lymphoma
Follicular Lymphoma
Updated: 05/21/2025
© Jun Wang, MD, PhD
General features
- Most common of non-Hodgkin lymphoma in US
- Originates from germinal/follicular center B cells
- May transform to diffuse large B cell lymphoma
Clinical presentations
- Nonspecific, including lymphadenopathy, mass, etc
- Bone marrow involvement common
Key morphological features of
tumor cells
- Packed irregular follicles
- Small to large lymphocytes
- Grading based on percentage of large tumor cells
Markers
- Positive: CD10, CD19, CD20, light chain restriction
- Negative: CD5, CD23, cyclin D1
- Bcl2 within follicles (Normally negative)
Genetic abnormalities
- Bcl2
- KMT2D
- MLL2
- t(14;18)(q32;q21): IgH/bcl2, Overexpressing bcl2
Negative prognosis indicator
- Marrow involvement
- Anemia
- High b-microglobulin
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