Langerhans cell histiocytosis

Langerhans cell histiocytosis
Updated: 08/30/2018
© Jun Wang, MD, PhD

General features
  • Idiopathic
  • Likely neoplastic
Clinical presentations
  • Tumor like lesions
  • Nodal or extranodal
Key risk factors
  • Smoking for pulmonary lesions
Key pathogenesis
  • Activating BRAF mutation
Key morphological features
Genetic abnormalities
  • Activating BRAF mutation
Negative prognosis indicator
  • Wide spread type: Letterer-Siwe disease
  • Extreme age
  • Lung involvement


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Anemia

Lymphoid neoplasms