Mantle Cell Lymphoma

Mantle Cell Lymphoma
Updated: 08/28/2024
© Jun Wang, MD, PhD

General features
  • Intermediate grade B cell lymphoma
  • Likely originated from naïve pregerminal center B lymphocyte
  • May have leukemic presentation
  • Likely relapses
Clinical presentations
  • Nonspecific, including generalized lymphadenopathy, mass, etc
  • Bone marrow/splenic involvement
  • Commonly advanced stage at presentation
Key morphological features of tumor cells
Markers
  • Positive: CD5, cyclin D1, CD19, CD20, light chain restriction
  • Negative: CD10, CD23
Genetic abnormalities
  • t(11;14)(q13;q32): CCND1 (cyclin D1)
Negative prognosis indicator
  • Blastic variant


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Contents

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Anemia

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Lymphoid neoplasms

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