Myeloproliferative neoplasms (MPN)

Myeloproliferative neoplasms (MPN)

Updated: 10/11/2022
© Jun Wang, MD, PhD

General features
  • Clonal myeloproliferation WITHOUT dysplasia
  • More common in adults, middle age and older
  • Progress to AML commonly from CML, but not  other types of MPN
  • Hepatosplenomegaly and lymphadenopathy due to extramedullary hematopoiesis
Key Laboratory findings
  • Initially hypercellular marrow with increased circulating blood cells
  • End in spent phase with marrow fibrosis and cytopenia
  • < 20% blasts
Key morphological features
  • Usually involving multiple lineages
  • Usually no dysplastic changes
Genetic abnormalities
  • Usually involving tyrosine kinase
Current classification


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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas...
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Anemia

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Lymphoid neoplasms

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