Plasmacytoma

Plasmacytoma 

Updated: 01/25/2023

© Jun Wang, MD, PhD

General features
  • AKA solitary myeloma
  • May progress to multiple myeloma
  • May be treated with local radiation therapy
Clinical presentations
  • Solitary monoclonal plasma cell mass
  • NO wide spread bone lesion
Key Laboratory findings
  • May have mildly elevated M protein in blood or urine
Key morphological features
  • Aggregates of abnormal plasma cells
  • Abnormal plasma cells: Perinueclear clearing
  • Mott cells: Plasma cells with grapelike cytoplasmic inclusions (Russell bodies)
  • Russell bodies: Cytoplasmic cherry red refractive round bodies
  • Dutcher bodies: Intranuclear crystalline rods
Markers
  • Positive: CD38, CD138, light chain restriction
  • Negative: CD19, CD20


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Contents

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Anemia

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Lymphoid neoplasms

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