Primary Effusion Lymphoma

Primary Effusion Lymphoma
Updated: 08/19/2024
© Jun Wang, MD, PhD

General features
  • Currently classified as KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
  • Also called body cavity large B cell lymphoma
  • Associated with HHV8 and advanced HIV infection
  • Commonly EBV+
  • High grade
  • Very aggressive
  • Poor prognosis.
  • Diagnosis based on clonal rearrangement or mutations of Ig heavy chains due to negative B-cell markers
Clinical presentations
  • Effusion, commonly single body cavity
  • Usually no identifiable tumor mass
Key pathogenesis
  • Human herpes virus 8
  • HIV
  • EB virus
Key Laboratory findings
  • High grade tumor cells in effusions, pleural, pericardial or peritoneal
Key morphological features of tumor cells
Markers
  • Positive: CD30, CD138, HHV8, EMA
  • Negative: CD5, CD19, CD20, CD79a

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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas...
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Anemia

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Lymphoid neoplasms

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