Aneurysmal bone cyst

Aneurysmal bone cyst
Updated: 07/31/2018
© Jun Wang, MD, PhD

General features
  • Uncommon
  • Common ages 1-20 years, no gender preference
  • May be secondary to trauma or other bone lesions
  • Benign but grows rapidly
  • May recur after curettage
Clinical presentations
  • Localized pain and swelling
  • Pathological fracture
Most common site
  • Metaphysis of long bones
  • Posterior vertebrae
Key radiologic findings
  • Expansile, lytic metaphyseal 
  • "Eggshell" sclerotic rim
Key morphological features
  • Large cystic spaces separated by septa containing giant cells and spindle cells
  • Cysts may be filled with blood
  • No endothelial lining cysts
Genetic abnormality
  • USP6 overexpression
Treatment
  • Surgery


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