Deep fibromatosis

Deep fibromatosis 

Updated: 08/18/2021

© Jun Wang, MD, PhD

General features
Clinical presentations
  • Usually painless mass
  • Dysfunction of surrounding tissue/organ due to infiltrative growth
  • Three types
Abdominal fibromatosis:
Arises within abdominal wall during or after pregnancy
May be associated with cesarean section scar
Extraabdominal fibromatosis:
Arises outside abdomen and abdominal wall, usually in muscles of shoulder, chest wall, back and thigh, equal gender frequencies
Intraabdominal fibromatosis:
 Mesenteric, pelvic or retroperitoneal locations, associated with Gardner's syndrome (familial adenomatous polyposis, multiple osteomas)
Often post-surgical
Key morphological features
Genetic abnormalities
  • Beta-catenin or APC mutation
  • May have trisomy 20 or 8
Treatment
  • Wide excision



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