Embryonoal rhabdomyosarcoma
Embryonoal rhabdomyosarcoma
Updated: 08/18/2021
© Jun Wang, MD, PhD
General features
- Most common rhabdomyosarcoma subtype
- Usually children ages 3-10 years
- Commonly in nasal and oral cavities, orbit, middle ear, prostate, paratesticular region
- Better prognosis if botryoid type
Clinical presentations
- Painless mass
- Most common location: head and neck paratesticular region
Key morphological features
Markers
- Positive for myogenin, desmin, myoD1
Genetic abnormalities
- PAX3
Botryoid variant
- AKA sarcoma botryoides
- Grape like mass
- Beneath mucosal membrane in walls of hollow structures (bladder, vagina, nasal cavity)
- Small tumor cells with eosinophilic granularcytoplasm and eccentric oval nuclei
Treatment
- Surgery
- Radiation
- Chemotherapy
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