Hemangioblastoma

Hemangioblastoma

Updated: 9/30/2025
© Jun Wang, MD, PhD

General features
  • Benign
  • Intracranial tumor
  • Peak age 20-50 years 
  • Associated with von Hippel-Lindau syndrome
  • Sporadic cases with somatic VHL mutation
Clinical presentations
  • Most common location: cerebellum
  • Can be seen in spinal cord, meninges
  • Symptoms associated with location due to mass effect
  • Multiple tumors in Von Hippel-Lindau syndrome patients
Pathogenesis
  • Loss of VHL promotes increased production of vascular endothelial growth factor and erythropoietin
Radiological features
  • MRI preferred
  • Usually well demarcated mass 
  • Enhancing mural nodule within a cyst
  • Might be solid 
Morphological features
Genetic abnormalities
  • VHL mutation
Management
  • Surgery
  • Radiation
  • Antiangiogenic therapy

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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Immunodeficiency disorders HIV infection   Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders Blood transfusion 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Ad...
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Anemia

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Myeloid neoplasms

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