Hemangioblastoma

Hemangioblastoma

Updated: 10/20/2020
© Jun Wang, MD, PhD

General features
Clinical presentations
  • Most common location: cerebellum
  • Can be seen in spinal cord, meninges
  • Symptoms associated with location due to mass effect
  • Multiple tumors in Von Hippel-Lindau syndrome patients
Pathogenesis
  • Loss of VHL promotes increased production of vascular endothelial growth factor and erythropoietin
Morphological features
Genetic abnormalities
  • VHL mutation
Management
  • Surgery
  • Radiation
  • Antiangiogenic therapy

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