Leiomyoma
Leiomyoma
Updated: 08/07/2020
© Jun Wang, MD, PhD
General features
- Benign tumor of smooth muscle
- Commonly in uterus, skin, subcutis, deep soft tissue and GI
- If multiple: Leiomyomata
Clinical presentations
- Mass
- Uterine leiomyoma may cause dysfunctional uterine bleeding or lower abdomen pressure-related symptoms
Key morphological features
- Well circumscribed firm mass
- Bulging trabecular cut surfaces
- Bundles or fascicles of spindled cells with minimal atypia
- Cigar shaped nuclei
- Usually no necrosis, no mitosis
Markers
- Positive for desmin, smooth muscle actin
Genetic abnormalities
- HMGIC, HMGIY, MED12 for uterine leiomyoma
Treatment
- Excision
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