Leiomyosarcoma

Leiomyosarcoma 

Updated: 08/07/2020

© Jun Wang, MD, PhD

General features
  • Malignant tumor of smooth muscle
  • Commonly in uterus, skin, subcutis, deep soft tissue and GI
  • Third most common retroperitoneal sarcoma after liposarcoma and undifferentiated pleomorphic sarcoma
  • Aggressive clinical behavior
  • Most common metastasis site: lung
Clinical presentations
  • Mass
  • Symptoms depending on location
Key morphological features
Markers
  • Positive for desmin, smooth muscle actin
Genetic abnormalities
  • Complex, commonly p53 mutation and p16 overexpression
Treatment
  • Excision
  • Chemotherapy
  • Radiation
Poor prognosis indicators
  • Retroperitoneal, mesenteric or other deep location
  • > 5 cm, except uterus
  • > 65 years
  • C-myc expression


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