Myxoid liposarcoma

Myxoid liposarcoma 

Updated: 08/18/2021

© Jun Wang, MD, PhD

General features
  • Used to be called myxoid/round cell liposarcoma
  • More common 40-50s
  • Adults in 20’s to 40’s
Clinical presentations
  • Most common location: Usually extremities, esp. proximal thigh
Pathogenesis
  • Deregulation of NF-kB pathway by FUS-DDIT3 chimeric protein
Key morphological features
Markers
  • S-100
Genetic abnormalities
  • FUD-DDIT3
Treatment
  • Wide excision
  • Raiotherapy/chemotherapy
Poor prognostic factors
  • Poorly differentiated (round cell) component
  • Large size, necrosis, high Ki-67 index, p53 overexpression

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