Nodular fasciitis

Nodular fasciitis
Updated: 08/07/2020
© Jun Wang, MD, PhD

General features
  • Believed to be reactive proliferation of fibroblasts and myofibroblasts
  • Usually young adults
  • History of previous trauma
  • Low risk of recurrence
Clinical presentations
  • Rapid growth, raising concern of malignancy
  • Usually self-limited
  • Most common sites: flexor arm, chest, back, etc
  • Commonly arising from superficial fascia
Key pathogenesis
  • Probably a transient neoplasm
Key morphological features
Differential diagnosis
  • Other sarcomas (high cellularity, necrosis, atypia, brisk mitosis, etc)
Genetic abnormalities
  • Balanced translocation t(17;22)(p13;q13) resulting in MYH9-USP6 gene fusion
Treatment
  • Excision



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