Pleomorphic rhabdomyosarcoma

Pleomorphic rhabdomyosarcoma
Updated: 08/07/2020
© Jun Wang, MD, PhD

General features
  • High grade tumor composed of undifferentiated cells
  • Rapid growth
  • Usually in patients older than 50
  • Poor prognosis
Clinical presentations
  • Painless mass
  • Most common location: lower extremity
Key morphological features
Markers
  • Positive for myogenin, desmin, myoD1
Genetic abnormalities
  • Complex karyotype
Treatment
  • Combination of surgery, radiation and chemotherapy

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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas M
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Anemia

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Lymphoid neoplasms

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