Schwannoma

Schwannoma 

Updated: 08/07/2020

© Jun Wang, MD, PhD

General features
  • Benign nerve sheath tumor arising from differentiated Schwann cells
  • Most commonly 20 - 50 years old
  • Majority are sporadic, may be associated with neurofibromatosis II (NF2) or Carney complex
Clinical presentations
  • Mass with abnormal sensation
  • Commonly in limbs, especially upper limbs, head and neck
  • Deep tumor commonly in posterior mediastinum or retroperitoneum
Pathogenesis
  • Abnormal activation of PI3K, RAS and RAC due to merlin inactivation
Genetic abnormality
  • Loss of function mutation of merlin at 22q12
Morphological features
Marker
  • Positive for S100


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Contents

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