Superficial fibromatosis

Superficial fibromatosis
Updated: 08/107/2020
© Jun Wang, MD, PhD

General features
  • Benign proliferation of fibroblasts/myofibroblasts with an infiltrating pattern
  • Different pathogenesis from deep fibromatosis, even with identical microscopic morphology
  • More common in men
  • Usually do not progress
Clinical presentations
  • Thickening or nodules, usually painless
  • Commonly arising from superficial fascia
  • May influence digit function if at palm or planta
  • Three types
Palmar fibromatosis (Dupuytren's contracture)
Plantar fibromatosis (Ledderhose's disease)
Penile fibromatosis (Peyronie's)
Key morphological features
Genetic abnormalities
  • NO beta-catenin or APC mutation 
Treatment
  • Excision
  • Incision to release contracture band



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