Synovial sarcoma

Synovial sarcoma
Updated: 08/07/2020
© Jun Wang, MD, PhD

General features
  • Biphasic malignant tumor with both epithelial and mesenchymal components
  • May be monophasic
  • More common in young adults, male
Clinical presentations
  • Mass near large joint
  • Most common sites: Knee and ankle
  • Joint rarely involved
Key morphological features
Markers
  • Positive for EMA and cytokeratin in both components
  • Vimentin in spindle cells
Genetic abnormalities
  • t(X;18)(p11.1;q11): SYT-SSX1 fusion
  • t(X;18)(p11.21;q11): SYT-SSX2 fusion genes
Treatment
  • Excision
  • Radiation
Poor prognosis indicators
  • High grade, high proliferative index
  • Necrosis
  • SYT-SSX1 fusion



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