Well differentiated liposarcoma

Well differentiated liposarcoma 

Updated: 02/27/2023

© Jun Wang, MD, PhD


General features
  • Called atypical lipomatous tumor if at periphery
  • Most common subtype of liposarcoma
  • Usually in age 40-60
Clinical presentations
  • Most common location: lower limbs and retroperitoneum
Key morphological features
Markers
  • S-100
Genetic abnormalities
  • Ring or giant chromosome/rod chromosomes from 12q13-15
  • Amplification of MDM2 and CDK4



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