Ataxia telangiectasia
Ataxia telangiectasia
Updated: 08/17/2020
© Jun Wang, MD, PhD
General features
- Autosomal recessive
Clinical presentations
- Progressive impairment of neurological deficits, vascular malformation and immunodeficiency affecting both B and T cells
- Recurrent sinopulmonary infections
- Development defects
Genetic abnormality
- Mutation of ATM
Pathogenesis
- Defected DNA repair, abnormal function of p53
Laboratory findings
- Thrombocytopenia
- Platelet dysfunction
Managements
- Treat infections
- Treat correlated abnormalities
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