Transient Hypogammaglobulinemia of Infancy

Transient Hypogammaglobulinemia of Infancy  
Updated: 08/17/2020
© Jun Wang, MD, PhD

General features
  • Relatively common, with male preponderance
  • Affects infants and young children
Clinical presentations
  • Can be asymptomatic
  • Symptoms developed 6 month after birth
  • Recurrent infections, including sinusitis, otitis media, bronchial infections
  • Usually intact T cell function, no opportunistic infections
  • Allegic or autoimmune disorders
  • Frequencies of infection markedly reduced after 3 years of age
Genetic abnormalities
  • Variable
  • Intrinsic B cell defect
  • Dysfunction of Th cell and suppressor T cells
  • Abnormality in the cytokines, such as IL-4, Il-6 etc
Pathogenesis
  • Unclear
Key Laboratory findings
  • Low serum IgG, with or without decreased IgA and IgM
  • Usually normal levels of lymphocyte subpopulations 
  • Normal response to immunizations
Managements
  • Continue routine immunization
  • Treat infections



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