Clear cell type renal cell carcinoma

Clear cell type renal cell carcinoma 

Updated: 10/06/2020

© Jun Wang, MD, PhD

General features
  • 70-80% of adult renal epithelial tumors
  • Derived from proximal convoluted tubule
  • Metastasis: commonly likely lung, lymph nodes, liver, bone, adrenal glands, etc, anytime, anywhere
Risk factors
Pathological features
  • Well circumscribed (pushing borders)
  • Orange/yellow (from lipid)
  • Commonly with hemorrhage, necrosis and calcification
  • Neoplastic cells with clear cytoplasm, arranged in nests with intervening blood vessels
Markers
  • Co-express cytokeratin and vimentin
Genetic abnormality
  • 3p- (3p25, VHL gene)


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Contents

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Anemia

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