Hypoplasia of kidney

Hypoplasia of kidney 

Updated: 10/05/2020

© Jun Wang, MD, PhD

General features
  • Congenital smaller kidney
  • Unilateral or bilateral
  • Reduced number of nephrons
  • Hypertrophied nephron
  • Often with dysplasia (hypodysplasia)
Key pathogenesis
  • Probably developmental defect of metanephric renal blastema
Clinical features
  • Oligohydramnios
  • Presentations of renal impairment
  • May develop end-stage renal disease
Key morphological features
  • Reduced number of nephrons
  • Normal architecture
  • Hypertrophic glomeruli/tubules with
  • Thickened Bowman’s capsule
  • Abnormal glomerular basement membrane
  • Dysplasia common
Diagnosis
  • Image studies



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