MiT translocation subgroup carcinomas

MiT translocation subgroup carcinomas 

Updated: 10/07/2020

© Jun Wang, MD, PhD

General features
    • MiT: microphthalmia associated transcription factors
    • Gene fusion involving TFE3 transcription factor on Xp11.2 or TFEB gene fusion due to t(6;11)
    • Diagnosis requires FISH or PCR
    • More common in women
    • More common in pediatric and young adult population
    • Aggressive clinical course
    Pathological features
    • TFE3 rearrangement
      • Papillary and nested growth pattern
      • Eosinophilic and clear discohesive pseudostratified cells
    • t(6:11) TFEB
      •  Biphasic, small and large tumor cells
    Markers
    • Positive: TFE3, TFEB
    • May be positive: HMB45, melan A
    Genetic abnormality
    • Translocation involving X11p: TFE3 transcription facto
    • t(6:11): TFEB
    Diagnosis
    • FISH or PCR



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