NUT carcinoma

NUT carcinoma 

Updated: 10/12/2020

© Jun Wang, MD, PhD

General features
  • Formerly known as NUT midline carcinoma
  • Aggressive type of poorly differentiated squamous cell carcinoma
  • Named after molecular abnormality involving NUT (nuclear protein in testis) gene
  • Commonly midline location, including head and neck, mediastinum
  • Metastasis common
Clinical presentations
  • Mass related symptoms
Key morphological features
Marker
  • Nuclear expression of NUT
Genetic abnormality
  • Nuclear protein of the testis (NUT) at 15q14
Diagnosis
  • Morphology
  • Molecular tests (fluorescence in situ hybridization) for translocations involving NUT
Treatment
  • No effective treatment


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