Oncocytoma
Oncocytoma
Updated: 10/06/2020
© Jun Wang,
MD, PhD
General features
- Most common benign solid renal tumor
- Probably arising from intercalated cells
- More common in men
- May be associated with tuberous sclerosis complex (TSC) and Birt-Hogg-Dube syndrome if multiple and bilateral
- May coexist with renal cell carcinoma
Clinical presentations
- Usually asymptomatic
- Rarely presents with hematuria and dysuria
- Flank pain if large
Pathological findings
- Well circumscribed, unencapsulated, solid mass
- Stellate central scar
- Uniform round/polygonal cells
- Eosinophilic and granular cytoplasm and uniform small, round and central nuclei
- Tumor cells have abundant mitochondria
Markers
- Scattered or negative CK 7 (positive for chromophobe renal cell carcinoma)
- Negative: Hale’s colloidal iron stain (positive for chromophobe renal cell carcinoma)
Diagnosis
- Image studies
- Biopsy
Management
- Excision
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