Papillary type renal cell carcinoma

Papillary type renal cell carcinoma 

Updated: 10/06/2020

© Jun Wang, MD, PhD

General features
  • Originated from proximal or distal convoluted tubule
  • May be hereditary
  • Commonly multifocal (80% of tumors), occasionally bilateral
  • Two types
    • Type I: better prognosis, MET mutation, simple epithelium
    • Type II: aggressive, associated with hereditary leiomyomatosis and renal cell cancer syndrome, pseudostratified epithelium
  • Prognosis better than clear cell carcinoma
Pathological features
Genetic abnormality
  • MET
  • Frequently trisomy 7, 17


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