Papillary type renal cell carcinoma
Papillary type renal cell carcinoma
Updated: 10/06/2020
© Jun Wang, MD, PhD
General features
- Originated from proximal or distal convoluted tubule
- May be hereditary
- Commonly multifocal (80% of tumors), occasionally bilateral
- Two types
- Type I: better prognosis, MET mutation, simple epithelium
- Type II: aggressive, associated with hereditary leiomyomatosis
and renal cell cancer syndrome, pseudostratified epithelium
- Prognosis better than clear cell carcinoma
Pathological features
- Thick capsule
- Papillary or tubulopapillary tumor lined by simple epithelium with low nuclear grade (type I) or pseudostratified epithelium with more pleomorphic nuclei (type II)
- Foamy macrophages and intracellular hemosiderin
Genetic abnormality
- MET
- Frequently trisomy 7, 17
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