Solitary fibrous tumor

Solitary fibrous tumor 

Updated: 02/17/2023

© Jun Wang, MD, PhD

General features
  • Pleural based, but usually NO pleural effusion
  • Most likely from submesothelial mesenchyme
  • Not associated with asbestos
  • May occur at other locations
  • May cause death due to extensive intrathoracic growth or malignant type
  • Aggressive if malignant
Key clinical features
  • May be asymptomatic
  • Nonspecific pulmonary symptoms including cough, shortness of breath, or chest pain, etc
  • Associated with pulmonary osteoarthropathy, digital clubbing and hypoglycemia, which regress after tumor resection
Key morphological features
Markers
  • Positive: CD34, CD99, STAT 6, vimentin
  • Negative: Cytokeratin
Genetic abnormality
  • Fusion of NAB2-STAT6 
Treatment
  • Surgery


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Contents

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