Squamous papilloma and papillomatosis

Upper respiratory squamous papilloma and papillomatosis 

Updated: 10/12/2020 

© Jun Wang, MD, PhD

General features
  • Warty outgrowths of surface epithelium
  • More common in men
  • Commonly multiple in children, but single in adult
  • Likely recur
Etiology
  • Squamous neoplasm associated with HPV, especially HPV 6 and 11
Clinical presentations
  • Airway obstruction or voice change
Key pathogenesis
  • HPV associated tumorigenesis
Key morphological features

(Image credit: Nephron [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)])
  • Fibrovascular cores
  • Well-differentiated squamous epithelium with koilocytotic change
  • Dysplasia may be seen in adults
Treatment
  • Goals of therapy: Relieve airway obstruction, improve voice quality, and facilitate remission
  • Surgery
  • Antiviral agent: Cidofovir


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