Atypical ductal hyperplasia
Atypical ductal hyperplasia
Updated: 12/10/2018
© Jun Wang, MD, PhD
General features
- Neoplastic intraductal lesion with architectural and cytological features suggestive but not diagnostic of ductal carcinoma in situ
- May be multicentric
- Higher risk of carcinoma
Clinical presentations
- No specific clinical features
- Microcalcification/architecture changes in mammogram
Key morphological features
- Less than 2-3 mm, if larger, diagnosed as ductal carcinoma in situ
- Micropapillae, tufts, bridges, solid and cribriform patterns
- Monomorphic cells with rounded or ovoid nuclei
- NO cytological atypia
- Intact myoepithelial cell layer (marked by positive reactivity to CD10, p63)
Marker
- Negative for keratin 903 (positive in usual ductal hyperplasia)
Treatment
- Surgery to rule out accompanying carcinoma
- Follow up
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