Atypical ductal hyperplasia

Atypical ductal hyperplasia
Updated: 12/10/2018
© Jun Wang, MD, PhD

General features
  • Neoplastic intraductal lesion with architectural and cytological features suggestive but not diagnostic of ductal carcinoma in situ
  • May be multicentric
  • Higher risk of carcinoma
Clinical presentations
  • No specific clinical features
  • Microcalcification/architecture changes in mammogram
Key morphological features
  • Less than 2-3 mm, if larger, diagnosed as ductal carcinoma in situ
  • Micropapillae, tufts, bridges, solid and cribriform patterns
  • Monomorphic cells with rounded or ovoid nuclei
  • NO cytological atypia
  • Intact myoepithelial cell layer (marked by positive reactivity to CD10, p63)
Marker
  • Negative for keratin 903 (positive in usual ductal hyperplasia)
Treatment
  • Surgery to rule out accompanying carcinoma
  • Follow up



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