Chorioamnionitis

Chorioamnionitis
Updated: 12/03/2018
© Jun Wang, MD, PhD

General feature
  • Associated with premature rupture of membranes
  • More frequent and severe with younger gestational age
  • Major cause of fetal/neonatal infection, stillbirth, prematurity and perinatal morbidity and mortality
Etiology
  • Bacterial infection of amnion and chorion membranes
  • Two paths of infection: Ascending or transplacental
  • Commonly group B streptococci, Listeria monocytogenes and fusobacterium, mixed microbes common
Clinical presentations
  • Signs of infection: fever, leukocytosis
  • Baseline fetal tachycardia
Pathological findings
  • Opaque membranes with yellow-green discoloration and cloudy amniotic fluid
  • Neutrophilic infiltrate of amnions or chorionic villi
Treatment
  • Antibiotics
  • Expedited delivery
  • Infected neonatals may need to be treated at NICU


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