Choriocarcinoma

Choriocarcinoma
Updated: 12/04/2018
© Jun Wang, MD, PhD

General features
  • Carcinoma derived from trophoblastic
  • Secondary to a prior pregnancy (normal or abnormal)
  • Most commonly arising from prior moles
  • May from prior abortions, normal pregnancies, ectopic pregnancies or teratomas
  • More common in African American, and women older than 40
  • Higher incidence in India, Mexico, Paraguay and Sweden
  • Most common metastatic sites: Lungs, vagina, brain, liver, kidney and bowel
Clinical presentations
  • Vaginal bleeding
  • Brown, foul-smelling discharge
Key Laboratory findings
  • High serum hCG
Key morphological features
  • Fleshy, yellow-white tumor with necrosis and hemorrhage
  • Markedly atypical cytotrophoblasts and syncytiotrophoblasts with nuclear pleomorphism, hyperchromasia and prominent nucleoli
  • High mitotic activity
Markers
  • Positive: hCG, cytokeratin
  • Negative: PLAP
Treatment
  • Chemotherapy
  • Radiation therapy
  • Surgery
  • Monitoring with serum hCG


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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4. Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas Multiple endocrine neoplasms 14. B
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Female genital tract

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