Choriocarcinoma

Choriocarcinoma
Updated: 12/04/2018
© Jun Wang, MD, PhD

General features
  • Carcinoma derived from trophoblastic
  • Secondary to a prior pregnancy (normal or abnormal)
  • Most commonly arising from prior moles
  • May from prior abortions, normal pregnancies, ectopic pregnancies or teratomas
  • More common in African American, and women older than 40
  • Higher incidence in India, Mexico, Paraguay and Sweden
  • Most common metastatic sites: Lungs, vagina, brain, liver, kidney and bowel
Clinical presentations
  • Vaginal bleeding
  • Brown, foul-smelling discharge
Key Laboratory findings
  • High serum hCG
Key morphological features
  • Fleshy, yellow-white tumor with necrosis and hemorrhage
  • Markedly atypical cytotrophoblasts and syncytiotrophoblasts with nuclear pleomorphism, hyperchromasia and prominent nucleoli
  • High mitotic activity
Markers
  • Positive: hCG, cytokeratin
  • Negative: PLAP
Treatment
  • Chemotherapy
  • Radiation therapy
  • Surgery
  • Monitoring with serum hCG


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