Endometrial stromal tumor
Endometrial stromal tumor
Updated: 12/16/2020
© Jun Wang, MD, PhD
General features
- Benign: endometrial stromal nodule
5th to 6th decades
Excellent prognosis
- Malignant: endometrial stromal sarcoma
40-50 years
Rearrangements of JAZF1, SUZ12, PHF1, and
EPC1, causing abnormal oncogene expression
Commonly recur and metastasize
Clinical presentations
- Benign: endometrial stromal nodule
Asymptomatic, usually incidental finding
- Malignant: endometrial stromal sarcoma
Abnormal uterine bleeding, pelvic
pain/pressure, and/or uterine mass
Pathological findings
- Benign: endometrial stromal nodule
Well-circumscribed growth, may be polypoid
No cytological atypia
- Malignant: endometrial stromal sarcoma
Low-grade, high-grade, undifferentiated
Necrosis
Treatment
- Malignant:
- Surgery
- Chemotherapy
- Radiation therapy
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