Follicular thyroid carcinoma
Follicular thyroid carcinoma
Updated: 12/13/2018
© Jun Wang, MD, PhD
General features
- More common in women, peak age older than papillary CA
- Risk factors: radiation exposure, iodine deficiency, older age, PTEN mutation
- Usually excellent prognosis
- Indicators of poor prognosis:
- Distant metastases
- Age > 45 years
- Extensive vascular invasion,
- Poorly differentiated or widely invasive tumors, etc
Clinical features
- Painless nodule or mass in neck or cervical node
Radiologic features
- Usually cold on scan
Pathological features
- Usually solitary
- Encapsulated nodule, focally hemorrhagic
- Follicular differentiation
- NO papillary nuclear features
- Evidence of invasion
- Hurthle cell variant: more than 75% hurthle cell changes
Marker
- Positive for thyroglobulin, TTF1
- Negative for calcitonin
Molecular abnormality
- PTEN
- PAX8
- RAS/PI3K
Treatment
- Total thyroidectomy
- Radioactive iodine
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