Intraductal papilloma


Intraductal papilloma
Updated: 12/10/2018
© Jun Wang, MD, PhD

General features
  • Benign
  • Intraductal proliferation of epithelial and myoepithelial cells
  • Usually mid age
Clinical presentations
  • Bloody nipple discharge
Key morphological features
  • Fibrovascular connective tissue core
  • Covered by epithelial and myoepithelial cells
  • NO cytological atypia
  • Intact myoepithelial cell layer (marked by positive reactivity to CD10, p63)
Treatment
  • Observation if small
  • Excision if large, or presence of atypia
  • Excision if found on core biopsy



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