Malignant mixed müllerian tumor
Malignant mixed müllerian tumor
Updated: 12/16/2020
© Jun Wang, MD, PhD
General features
- Biphasic tumor with malignant epithelial and stromal components (carcinosarcoma)
- Postmenopausal women
- Associated with chronic estrogen stimulation
- Highly aggressive
Clinical presentations
- Asymptomatic
- Or triad of pain, uterine bleeding, and rapid enlargement of uterus
Pathological findings
- Epithelial components: Atypical cells with glandular differentiation
- Stromal components: Atypical poorly differentiated spindle cells with high nuclear/cytoplasmic ratio and hyperchromic irregular nuclei
- Necrosis and mitosis
Laboratory finding
- Elevated Serum CA125
Treatment
- Surgery
- Chemotherapy
- Radiation therapy
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