Placental site nodule and placental site trophoblastic tumor

Placental site nodule and placental site trophoblastic tumor 

Updated: 01/26/2026

© Jun Wang, MD, PhD

Placental site nodule
  • Composed of benign intermediate trophoblast cells
  • Usually an incidental finding
  • Remnant of implantation site that failed to involute
  • May be identified many years after pregnancy
  • May present with abnormal bleeding
  • Positive for cytokeratin
  • Negative for hCG 

Placental site trophoblastic tumor
  • Neoplastic transformation of implantation-site intermediate trophoblast
  • Reproductive age women (occasionally age 50+)
  • Present with amenorrhea or abnormal bleeding with enlarged uterus
  • Persistently elevated serum hCG
  • Diploid, express hCG (focally positive) and cytokeratin

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