Malakoplakia of bladder
Malakoplakia of bladder
Updated: 01/26/2021
© Jun Wang, MD, PhD
General features
- Rare histiocytic diseas
- Common in GU tract, particularly bladder
- May occur in other locations
- More common in immunocompromised, women
Key pathogenesis
- Defects in histiocytic phagocytic or degradative functions of bacteria
- Intracellular deposition of iron and calcium may occur
Clinical presentations
- Urinary symptoms and urinary tract infection
Key morphological features
- Soft raised plaque
- Foamy histiocytes with PAS+ granular eosinophilic cytoplasm in lamina propria
- Histiocytes with increased number of phagosomes containing non-digested bacteria, Michaelis-Gutmann bodies (iron containing, cytoplasmic laminated mineralized concretions)
Treatment
- Antibiotics that concentrate in macrophages
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