Squamous cell carcinoma of bladder

Squamous cell carcinoma of bladder 

Updated: 01/27/2021

© Jun Wang, MD, PhD

General features
  • <5% of bladder tumors in US
  • More common in Egypt/Sudan
  • Diagnosed only if solely squamous cell component
  • Commonly lateral walls and trigone
  • Arises from squamous metaplasia
Risk factors
  • Cigarette smoking
  • Chronic infection
  • Bladder exstrophy, neurogenic bladder, chronic indwelling catheters
  • Schistosoma haematobium infection in Egypt/Sudan
Clinical presentations
  • Painless hematuria
  • Irritative voiding syndrome
Key morphological features
Genetics
  • Complex, nonspecific
Treatment
  • Surgery
  • Preoperative radiation therapy may be considered


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