Acanthosis nigricans
Acanthosis nigricans
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Updated: 01/31/2020
© Jun Wang,
MD, PhD
General features
- Increased pigmentation of skin
- Usually in patients > 40
- May be associated with endocrine diseases, congenital disorders and visceral malignancies, especially GI
- May occur as inherited disorder
- Most are "benign" type, either autosomal dominant or associated with resistance to insulin, including diabetes, obesity and Cushing's disease
Clinical features
- Brown, velvety and verrucous plaques
- Commonly in axillae, back of neck and other skin folds
- Oral mucosa (lips and tongue) may be affected
Pathological features
- Papillomatous epidermal proliferation
- Hyperpigmentation
- NO melanocytic proliferation
Management
- Focus on underlying disorders
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