Appendix tumors
Appendix tumors
Updated: 03/03/2021
© Jun Wang, MD, PhD
General
features
- Most commonly carcinoid
- Mucinous tumors occur
Carcinoid
- Most common
- Peak incidence at 20-39 years
- Carcinoid syndrome may present
- Rarely metastases
- Nested pattern, nuclei with salt and pepper pattern chromatin
- Express neuroendocrine markers (chromogranin, synaptophysin, CD56)
- Treatments: Appendectomy if less than 1 cm, right hemicolectomy if > 2 cm or positive surgical margin/pronounced mesoappendiceal spread
Pseudomyxoma
peritonei
- Clinical syndrome, not a histologic diagnosis
- Extravasation of mucin into abdomen outside of right lower quadrant
- Clonally derived from associated mucinous tumor, usually of appendix
- May be associated with ovarian mucinous tumors, although these are probably metastatic from appendix or other GI sites
- Poor prognosis associated with infection, intestinal obstruction, peritonitis
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