Benign nonproliferative melanocytic disorders

Benign non proliferative melanocytic disorders 

Updated: 03/18/2021

© Jun Wang, MD, PhD

General features
  • Abnormal pigmentation
  • Majority diagnosed clinically
Freckle
  • Sun exposed skin
  • More common in people with fair skin and red hair
  • Appears in early childhood
  • Fades in winter, darkens in summer
  • Small tan-red or light brown macules
  • Mild hyperpigmentation of basal keratinocytes, normal architecture
  • NO increase in number of melanocytes
Vitiligo
Melasma
  • Symmetrical hypermelanosis
  • Most common in women during reproductive age
  • Associated with sun exposure, elevated estrogen activity in affected skin, photosensitizing medications, etc
  • May have genetic predisposition
  • Most common site: face
  • Treatment: topical hydroquinine cream, avoid sun exposure, avoid estrogen exposure



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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4. Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas Multiple endocrine neoplasms 14. B
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