Benign nonproliferative melanocytic disorders

Benign non proliferative melanocytic disorders 

Updated: 03/18/2021

© Jun Wang, MD, PhD

General features
  • Abnormal pigmentation
  • Majority diagnosed clinically
Freckle
  • Sun exposed skin
  • More common in people with fair skin and red hair
  • Appears in early childhood
  • Fades in winter, darkens in summer
  • Small tan-red or light brown macules
  • Mild hyperpigmentation of basal keratinocytes, normal architecture
  • NO increase in number of melanocytes
Vitiligo
Melasma
  • Symmetrical hypermelanosis
  • Most common in women during reproductive age
  • Associated with sun exposure, elevated estrogen activity in affected skin, photosensitizing medications, etc
  • May have genetic predisposition
  • Most common site: face
  • Treatment: topical hydroquinine cream, avoid sun exposure, avoid estrogen exposure



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